Minimum effective bolus dose of oxytocin during elective Caesarean delivery

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Minimum effective bolus dose of oxytocin during elective Caesarean delivery.

BACKGROUND The aim of this study was to determine the lowest effective bolus dose of oxytocin to produce adequate uterine tone (UT) during elective Caesarean delivery (CD). METHODS Seventy-five pregnant patients undergoing elective CD under spinal anaesthesia were randomized to receive oxytocin (0.5, 1, 3, 5 units) or placebo. UT was assessed by a blinded obstetrician as either adequate or in...

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Oxytocin requirements at elective cesarean delivery: a dose-finding study.

OBJECTIVE Oxytocin is frequently used by intravenous bolus and infusion to minimize blood loss and prevent postpartum hemorrhage at cesarean delivery. Current dosing regimens are arbitrary whereas large doses may pose a serious risk to the mother. The purpose of this study was to estimate the minimum effective intravenous bolus dose of oxytocin (ED90) required for adequate uterine contraction a...

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Oxytocin bolus versus oxytocin bolus and infusion for control of blood loss at elective caesarean section: double blind, placebo controlled, randomised trial

OBJECTIVES To determine the effects of adding an oxytocin infusion to bolus oxytocin on blood loss at elective caesarean section. DESIGN Double blind, placebo controlled, randomised trial, conducted from February 2008 to June 2010. SETTING Five maternity hospitals in the Republic of Ireland. PARTICIPANTS 2069 women booked for elective caesarean section at term with a singleton pregnancy. ...

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Timing of repeat elective caesarean delivery and neonatal respiratory outcomes.

Compared with other industrialised countries, Italy has one of the highest caesarean delivery rates, which increased from 26.1% in 1995 to 38.3% in 2005. While the overall effect of this mode of delivery on neonatal respiratory outcomes among term newborns is well known, few studies have compared the impact of gestational age at delivery on respiratory morbidity (ie, at 37 and 38 weeks’ gestati...

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OBSTETRICS Haemodynamic effects of repeated doses of oxytocin during Caesarean delivery in healthy parturients

Results. Twenty women required a second bolus of oxytocin 5 u. Both the first and the second doses produced clinically and statistically significant haemodynamic changes, but the haemodynamic changes induced by the second dose were smaller than after the first dose. The mean maximal change in CO after the first and second doses were 94% (CI 70–117) and 42% (CI 33–52), respectively (P,0.0001), a...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 2010

ISSN: 0007-0912

DOI: 10.1093/bja/aeq004